By reviewing the development from human genome project to precision medicine, we can have a more comprehensive and accurate understanding on comparative medicine, thus provide important enlightenment for more precise and efficient comparative medicine research. Starting from the development from human genome project to precision medicine, this paper summarized and analyzed the development trend of comparative medicine, that is, humanization of laboratory animals and personification of animal models. Moreover, the paper pointed out that under the challenge of big data era, comparative medicine research should play its “cross convergence” characteristics, achieve breakthroughs in research methods and technologies, and improve the efficiency and quality of human health research.

Laboratory animal is one of the important basic scientific research conditions to support the science and technology innovation in the fields of life science and biomedicine. The new and rapid development trend of scientific and technological innovation in China calls for strengthening the strategic position of laboratory animal resources, accurately grasping the creation mode of laboratory animal resources, further improving the policy system and operation mechanism conducive to the creation and development of laboratory animal resources, as well as the service platform for the preservation and sharing of laboratory animal resources, aiming to improve the service level of laboratory animal resources for national scientific and technological innovation.