Development Trend and Challenge of Comparative Medicine from Human Genome Project to Precision Medicine

doi:10.12300/j.issn.1674-5817.2021.022

Laboratory Animal and Comparative Medicine ›› 2021, Vol. 41 ›› Issue (1): 1-8.DOI: 10.12300/j.issn.1674-5817.2021.022

Special Issue: 专家论坛；大咖谈

• 40th Anniversary Expert Forum • Next Articles

Development Trend and Challenge of Comparative Medicine from Human Genome Project to Precision Medicine

ZHAO Guoping^{1, 2, 3}

1. Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China;
2. Key Laboratory of Synthetic Biology, Chinese Academy of Sciences, Shanghai 200032, China;
3. Biomedical Big Data Center, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China

Received:2020-11-21 Revised:2021-01-25 Online:2021-02-25 Published:2021-02-26
Contact: ZHAO Guoping, E-mail: gpzhao@sibs.ac.cn

Abstract

Abstract: By reviewing the development from human genome project to precision medicine, we can have a more comprehensive and accurate understanding on comparative medicine, thus provide important enlightenment for more precise and efficient comparative medicine research. Starting from the development from human genome project to precision medicine, this paper summarized and analyzed the development trend of comparative medicine, that is, humanization of laboratory animals and personification of animal models. Moreover, the paper pointed out that under the challenge of big data era, comparative medicine research should play its “cross convergence” characteristics, achieve breakthroughs in research methods and technologies, and improve the efficiency and quality of human health research.

Key words: Human genome project, Precision medicine, Comparative medicine, Development trend

CLC Number:

R-332
Q95-33

ZHAO Guoping. Development Trend and Challenge of Comparative Medicine from Human Genome Project to Precision Medicine[J]. Laboratory Animal and Comparative Medicine, 2021, 41(1): 1-8.

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References

[1] DULBECCO R.A turning point in cancer research: Sequencing the human genome[J]. Science, 1986, 231(4742):1055-1056. DOI:10.1126/science.3945817.
[2] 黄辛. 写在人类基因组南方中心成立10周年之际[N]. 科学时报, 2008-11-19 (A2). 写在人类基因组南方中心成立10周年之际[N]. 科学时报, 2008-11-19 (A2). http://news.sciencenet.cn/htmlnews/2008/11/213385.html.
[3] 中华人民共和国科学技术部, 卫生部. 人胚胎干细胞研究伦理指导原则: 国科发生字〔2003〕460号[A/OL]. (2003-12-24)[2020-01-01]. http://www.most.gov.cn/fggw/zfwj/zfwj2003/200512/t20051214_54948.htm.
[4] 杨丽霞, 黄宗涛, 刘铜华, 等. 代谢性疾病实验动物模型的建立与评价[J]. 中国实验动物学报, 2009, 17(4):318-322. DOI:10.3969/j.issn.1005-4847.2009.04.020.
[5] HUANG H Q, XIE Z H, BOUE S M, et al.Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model[J]. J Agric Food Chem, 2013, 61(24):5772-5782. DOI:10.1021/jf400557p.
[6] LU S H, GUAN J H, HUANG Y L, et al.Experimental study of antiatherosclerosis effects with hederagenin in rats[J]. Evid Based Complement Alternat Med, 2015, 2015:456354. DOI:10.1155/2015/456354.
[7] WU J H, ZOU H, STRONG J A, et al.Bimodal effects of MK-801 on locomotion and stereotypy in C57BL/6 mice[J]. Psychopharmacology, 2005, 177(3):256-263. DOI:10.1007/s00213-004-1944-1.
[8] WANG K, SONG H, JIN M, et al.Chronic alcohol consumption from adolescence to adulthood in mice: hypothalamic gene expression changes in insulin-signaling pathway[J]. Alcohol, 2014, 48(6):571-578. DOI:10.1016/j.alcohol.2014.07.001.
[9] WANG K, SONG H G, JIN M L, et al.Chronic alcohol consumption from adolescence to adulthood in mice— Hypothalamic gene expression changes in insulin-signaling pathway[J]. Alcohol, 2014, 48(6):571-578. DOI:10.1016/j.alcohol.2014.07.001.
[10] GUO N, GU X, ZHAO J, et al.Maxillary nerve compression in cynomolgus monkey Macaca fascicularis: altered somatic sensation and peripheral nerve firing[J]. BMC Neurosci, 2012, 13:150. DOI:10.1186/1471-2202-13-150.
[11] ZOU H, LIU M, LUAN Y, et al.Pattern of novel object exploration in cynomolgus monkey Macaca fascicularis[J]. J Med Primatol, 2017, 46(2):19-24. DOI:10.1111/jmp.12251.
[12] SCEARCE-LEVIE K, SANCHEZ P E, LEWCOCK J W.Leveraging preclinical models for the development of Alzheimer disease therapeutics[J].Nat Rev Drug Discov, 2020, 19(7):447-462. DOI:10.1038/s41573-020-0065-9.
[13] WANG X Y, SUN G Q, FENG T, et al.Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression[J]. Cell Res, 2019, 29(10):787-803. DOI:10.1038/s41422-019-0216-x.
[14] 张国庆, 李亦学, 王泽峰, 等. 生物医学大数据发展的新挑战与趋势[J]. 中国科学院院刊, 2018, 33(8):853-860. DOI:10.16418/j.issn.1000-3045.2018.08.013.
[15] 习近平.在科学家座谈会上的讲话[EB/OL]. 新华网, 2020-09-11. http://www.xinhuanet.com/politics/2020-09/11/c_1126483997.htm.

Development Trend and Challenge of Comparative Medicine from Human Genome Project to Precision Medicine

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