Establishment of Stress Induced Cardiomyopathy Model by Stimulation of Vagus Nerve with Electricity Signal in Rabbit

doi:10.3969/j.issn.1674-5817.2016.03.005

Abstract

Abstract: Objective To establish the stress induced cardiomyopathy (SIC) model in rabbit via the stimulation of vagus nerve by using electricity signal. Methods Ten femaleNew Zealand White rabbits at the age of 2 months were randomly divided into control group and experimental group. The vagus nerve of the experimental group rabbits were exposured and stimulated intermittently by using electrical signal. The rabbit model were evaluated by electrocardiogram (ECG), necropsy and pathological observation of myocardial tissue. Results The ECG at 1 day after operation showed that heart rate of rabbit in experimental group was faster than that of the control group. Meanwhile, apical myocardial in the experimental group became significant thinner than that in control group at one month after operation(0.83±0.12 mm vs 1.55±0.11 mm, P<0.05). In addition, myocardial tissue of rabbits in experimental group were showed typical changes of stress induced cardiomyopathy. Conclusion The SIC rabbit model can be successfully established via stimulating the vagus nerve by using electricity signal.

Key words: Stress induced cardiomyopathy (SIC), Rabbit, Animal model, Vagus nerve

CLC Number:

R-331Q95-33

GUO Rui-wei,YANG Li-xia,XI Yin-yan,et al. Establishment of Stress Induced Cardiomyopathy Model by Stimulation of Vagus Nerve with Electricity Signal in Rabbit[J]. Laboratory Animal and Comparative Medicine, 2016, 36(3): 186-189. DOI: 10.3969/j.issn.1674-5817.2016.03.005.

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Establishment of Stress Induced Cardiomyopathy Model by Stimulation of Vagus Nerve with Electricity Signal in Rabbit

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