Abstract: Male KM mice were contaminated by ip with NaV0₃ （3 mg/kg） for six weeks.The results showed that the total quantity，the survival rate and motility of sperm in the model group mice were decreased significantly compared with those of the control group （P＜0.01），the deformity rate of sperm in model group mice increased （P＜0.01）. Then，the model mice were treated by traditional chinese medicine, Modified Tianxiong Powder （MTP） （25 ml·kg^_1·d^-1）. The quality of epididymidis sperm, the contents of Vanadate （Va） in testis and testosterone were analysed after five weeks. The results showed that it hadn’t different in the total quantity of sperm，the survival rate of sperm, and their motility between the group treated by MTP and the normal group,the content of testosterone in the serum in the group treated by MTP was higher than in the model group.The results indicate that MTP can reverse the change in the sperm of male mice with Va.

Key words: Modified Tianxiong powder, Vanadate, Epididymidis sperm.