Abstract: Objective To investigate the effects of sodium cholate on the mother and fetuse in intrahe-patic cholestasis of pregnancy （ICP）. Method Pregnant ewes were served as animal models. High dose of sodium cholate was infused to pregnant ewes through jugular fistula. Results The pruritus, fetal distress, and intrauterine death appeared in the animal of treated group, which were similar with the symptoms of pregnancy women in ICP. Conclusion The sodium cholate could influence on the mother and fetuse of the ewes，and further confirmed sodium cholate was an important factor to induce symptoms of ICP.

Key words: Intrahepatic cholestasis of pregnancy, Intravenous infusion, Sodium cholate, Ewe, Fetus