Rodent Models of Colorectal Tumor and Evaluation System of Drugs

Laboratory Animal and Comparative Medicine ›› 2010, Vol. 30 ›› Issue (1): 60-67.

Rodent Models of Colorectal Tumor and Evaluation System of Drugs

1.Zhejiang Chinese Medical University Laboratory Animal Research Center, Hangzhou 310053,China;2.Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University,Hangzhou 310058, China; 3. Department of Anointestinal Surgery, The First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou 310003, China

Received:2009-03-17 Online:2010-01-31 Published:2010-01-31

Abstract

Abstract: In the present paper, common rodent models for colorectal cancer are systematically discussed and reviewed with regard to preparation methods, experimental observation means and drug evaluation system, etc. Additionally, the few disadvantage of animal model of human colorectal cancer are analyzed. The review will be beneficial for research in fields of colorectal cancer concerning carcino-genesis mechanism, chemopre vent ion, drug development.

Key words: Colorectal Tumor, Models, Drugs Evaluation System

ZHOU Wei-Min-1,SHENG Hong-Qiang-2,CHEN Wen-Bin-3,et al. Rodent Models of Colorectal Tumor and Evaluation System of Drugs[J]. Laboratory Animal and Comparative Medicine, 2010, 30(1): 60-67.

[1]	HE Miao, ZHANG Xuxing, WU Gang, ZHOU Yi, RAO Hao, HU Xiangyu. Analysis of Animal Models of Lumbar Spinal Stenosis Based on Clinical Characteristics of Traditional Chinese and Western Medicine [J]. Laboratory Animal and Comparative Medicine, 2026, 46(4): 541-552.
[2]	LI Desheng, ZHAO Yanguang. Research Progress in the Construction and Evaluation of Pig Depression Models [J]. Laboratory Animal and Comparative Medicine, 2026, 46(4): 515-530.
[3]	WANG Lu, WANG Qingjie, YANG Chunhong, ZHANG Yijian. Application of New Approach Methodologies in Biomedical Field and Their Implementation of "3R" Principle [J]. Laboratory Animal and Comparative Medicine, 2026, 46(4): 573-582.
[4]	PAN Linqin, DENG Xiangliang, LUO Yunxia. Advances in Integrative Translational Research on Animal Models of Ischemic Stroke in Traditional Chinese and Western Medicine [J]. Laboratory Animal and Comparative Medicine, 2026, 46(3): 344-356.
[5]	LI Hui. Advances in Animal Models for Biolinguistic Research [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 297-305.
[6]	LIAO Wangyue, LEI Shuang, LI Xuan, GUO Min, ZHOU Ruoran. Literature Analysis and Validity Assessment for Animal Models of Attention Deficit and Hyperactive Disorder [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 66-80.
[7]	CHEN Ziyi, SUN Hongyan, KANG Pinfang, WU Wenjuan. Research Advances in Construction Methods and Novel Technologies for Animal Models of Pulmonary Hypertension [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 81-93.
[8]	GAO Chaoqi, ZHU Zhibo, SUN Xiandong. Application Progress and Classification Analysis of Rat Vascular Remodeling Models [J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 542-550.
[9]	LIU Yang, CHENG Laiyang, GUO Zhongkun. Progress on Animal Models of Perimenopausal Syndrome Based on Traditional Chinese Medicine Disease-Syndrome Combination [J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 586-595.
[10]	LIU Yayi, JIA Yunfeng, ZUO Yiming, ZHANG Junping, LÜ Shichao. Progress and Evaluation of Animal Model of Heart Qi-Yin Deficiency Syndrome [J]. Laboratory Animal and Comparative Medicine, 2025, 45(4): 411-421.
[11]	PAN Yicong, JIANG Wenhong, HU Ming, QIN Xiao. Optimization of Surgical Procedure and Efficacy Evaluation of Aortic Calcification Model in Rats with Chronic Kidney Disease [J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 279-289.
[12]	LI Huiping, GAO Hongbin, WEN Jinyin, YANG Jinchun. Construction and Preliminary Application of Animal Disease Model Digital Atlas Database Platform [J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 300-308.
[13]	LUO Lianlian, YUAN Yanchun, WANG Junling, SHI Guangsen. Advances in Mouse Models of Amyotrophic Lateral Sclerosis [J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 290-299.
[14]	LIAN Hui, JIANG Yanling, LIU Jia, ZHANG Yuli, XIE Wei, XUE Xiaoou, LI Jian. Construction and Evaluation of a Rat Model of Abnormal Uterine Bleeding [J]. Laboratory Animal and Comparative Medicine, 2025, 45(2): 130-146.
[15]	YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen. Research Progress on Animal Models of Sepsis-Related Organ Injury [J]. Laboratory Animal and Comparative Medicine, 2024, 44(6): 636-644.

Rodent Models of Colorectal Tumor and Evaluation System of Drugs

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments