Laboratory Animal and Comparative Medicine ›› 2009, Vol. 29 ›› Issue (6): 424-428.

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The Generation and Application of Transgenic RNAi Mice

  

  1. 1. Biological Engineering College,East China University of Science and Technology, Shanghai 200237, China; 2. Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China
  • Received:2009-07-02 Online:2009-06-30 Published:2009-06-30

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Abstract: RNA interference (RNAi)has been extensively used for sequence-specific silencing of target gene. The generation of RNAi transgenic mice made it possible to knock down gene expression in mammalian species. This paper reviewed the generation of transgenic RNAi mice and its application. The contribution of RNAi transgenic mice to functional genomics and of its prospect for application were also discussed.

Key words: Trans gene, RNAi, Intracytoplasmic Sperm Injection