Effects of Astragalus Polysaccharides on B16-BL6 Melanoma Lung Metastasis in Mice

doi:10.3969/j.issn.1674-5817.2014.03.013

Laboratory Animal and Comparative Medicine ›› 2014, Vol. 34 ›› Issue (3): 232-234.DOI: 10.3969/j.issn.1674-5817.2014.03.013

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Effects of Astragalus Polysaccharides on B16-BL6 Melanoma Lung Metastasis in Mice

ZHAO Yong¹, ZHANG Lu², CAI Li-ping², XU Chen²

1. Shanghai Laboratory Animal Research Center,Shanghai 201203, China;
2. Laboratory Animal Center of the Second Military Medical University, Shanghai 200433, China

Received:2014-03-31 Online:2014-06-25 Published:2014-06-25

Abstract

Abstract: Objective To explore the effect and mechanism of different doses of astragalus polysaccharides on pulmonary metastasis of B16-BL6 melanoma in mice. Methods The B16-BL6 artificial pulmonary metastasis model was used to study the influence of different doses of astragalus polysaccharides on pulmonary metastasis of melanoma; exploring its possible mechanism by measuring the immune organ index variation after administration in mice. Results High dose of astragalus polysaccharide can significantly inhibit B16-the BL6 melanoma lung metastasis and increase the index of spleen in mice. Conclusion High dose of astragalus polysaccharides maybe inhibited the pulmonary metastasis of melanoma cells by enhancing immunity.

Key words: B16-BL6 cell, Astragalus polysaccharides, Pulmonary metastasis, Melanoma

CLC Number:

Q95-33

ZHAO Yong, ZHANG Lu, CAI Li-ping, XU Chen. Effects of Astragalus Polysaccharides on B16-BL6 Melanoma Lung Metastasis in Mice[J]. Laboratory Animal and Comparative Medicine, 2014, 34(3): 232-234.

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Effects of Astragalus Polysaccharides on B16-BL6 Melanoma Lung Metastasis in Mice

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