Observations on Distribution of Quantum Dots and Acute Toxicity in Rats

doi:10.3969/j.issn.1674-5817.2011.04.006

Laboratory Animal and Comparative Medicine ›› 2011, Vol. 31 ›› Issue (4): 255-258.DOI: 10.3969/j.issn.1674-5817.2011.04.006

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Observations on Distribution of Quantum Dots and Acute Toxicity in Rats

SUN Peng¹, LI Peng¹, ZHANG Xu-rui², QIAO Wei-wei³, ZHAO Xia⁴, ZHANG Yun-peng¹

1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China;
2. Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Fudan University, Shanghai 200433, China;
3. Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China;
4. Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai 200040,China

Received:2010-12-10 Online:2011-08-25 Published:2011-08-25

Abstract

Abstract: Objective To study the acute toxicity and the distribution of quantum dots in rats. Methods Six rats underwent quantum dots injection at the subcutaneous of upper limbs while the other six rats underwent physiological saline injection at the same sites. Two weeks observation and post-observation dissection were done on all of the twelve rats to confirm if there were any abnormities. The distribution of quantum dots was measured by inductively coupled plasma-mass spectrometry. Results No apparent toxicity was seen during two weeks' observation. The results of Cadmium assay showed that quantum dots mainly accumulated in the livers, spleens and kidneys of the rats. Conclusions The toxicity of quantum dots can be affected by many factors, which remain further research.

Key words: Quantum dots, Acute toxicity, Inductively coupled plasma-mass spectrometry

CLC Number:

Q95-33

SUN Peng, LI Peng, ZHANG Xu-rui, QIAO Wei-wei, ZHAO Xia, ZHANG Yun-peng. Observations on Distribution of Quantum Dots and Acute Toxicity in Rats[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 255-258.

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Observations on Distribution of Quantum Dots and Acute Toxicity in Rats

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