Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine

doi:10.12300/j.issn.1674-5817.2022.146

Abstract

Abstract:

Major depressive disorder is a serious disease that impacts human health worldwide. Traditional antidepressant medications are limited by the delayed onset of therapeutic effects and the unacceptable side effects. Recently, the rapid antidepressant effect of ketamine, which decreases depressive symptoms within hours, has been a very attractive finding in the field, but the underlying mechanisms mediating this rapid response remain unclear. Besides, the clinical application of ketamine still carries risks, such as addiction and deleterious side effects. In May 2022, Rawat et al. reported that the acute activation of adult-born immature granule neurons (ABINs) in the dentate gyrus played a key role in the rapid antidepressant effects of ketamine. This commentary reviews the important findings of this research and looks forward to the future work.

Key words: Major depressive disorder, Ketamine, Rapid antidepressant effect, Dentate gyrus, Adult-born immature granule neurons

CLC Number:

R-338

Sheng WEI, Xiwen GENG, Feng ZHAO, Zifa LI, Hao ZHANG, Minghui HU. Recent Research Progress of the Mechanism of Adult-born Immature Granule Neurons Underlying Rapid Antidepressant Effect of Ketamine[J]. Laboratory Animal and Comparative Medicine, 2022, 42(5): 377-383.

Figures/Tables 3

Figure1 Ketamine blocks the function of NMDA receptors, decreases neuronal bursting, and rescues depression-like phenotypesNote： This figure is based on published data ［4-5］, which was drawn by the authors of this article.

Figure 2 Schematic diagram of the experimental design of Rawat et al. (2022)Note： This diagram was generated based on published data ［13］， which was drawn by authors of this article.

Figure 3 Neural circuits involved in the antidepressant actions of ketamineNote： This figure is based on published data ［18， 22］， which was drawn by authors of this article. BLA， basolateral amygdala； BNST， bed nucleus of the stria terminalis； DRN， dorsal raphe nucleus； LHb， lateral habenula； MDT， mediodorsal nucleus of the thalamus； mPFC， medial prefrontal cortex； RMTg， rostromedial tegmental nucleus； vHPC， ventral hippocampus； VTA， ventral tegmental area.

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