Effect of Recombinant Growth Hormone on Nutritional Status and Pulmonary Function in COPD Rat

doi:10.3969/j.issn.1674-5817.2013.01.011

Abstract

Abstract: Objective To study the effect of gene recombinant growth hormone (GH) on nutritional status and lung function of chronic obstructive pulmonary disease (COPD) rats. Methods The COPD rats was established through smoking combined with lipopolysaccharide, 16 cases of COPD rats were randomly divided into 2 groups, group GH for growth hormone treatment (8 cases), daily subcutaneous injections of recombinant rat growth hormone 1 µg,7 days of continuous use, group NS (8 cases) with subcutaneous injection of physiological saline. Fifteenth days after treatment, the rat body weight, serum albumin (ALB), transferrin (TRF), prealbumin (PA), creatinine, blood urea nitrogen and glucose of all the rats were detected, and the lung function were evaluated. Results The COPD model conforms to the COPD basic pathological changes. In two groups before treatment weight, albumin, prealbumin, total protein, creatinine, blood urea nitrogen, blood glucose had no significant difference (P>0.05), body weight, albumin, prealbumin, total protein of growth hormone group increase has higher than the control group (P<0.05), creatinine, urea nitrogen were significantly decreased (P<0.05), the glucose increased before and after treatment with growth hormone group, but the difference was not statistically significant (P>0.05). Lung function (FEV0.3, FEV0.3/FVC, PEF) after treatment compared with the saline control group were significantly higher (P<0.05). Conclusions The growth hormone therapy can improve nutritional status and lung function of the stable phase of chronic obstructive pulmonary disease rat.

Key words: Recombinant growth hormone, Chronic obstructive pulmonary disease, Nutritional status, Lung function

CLC Number:

Q95-33

WEN Wen, LIU De-ling, GUAN Ze-jin, HUANG Yu-hai, CHEN Mei-lian, YE Jia, LAI Guo-xiang. Effect of Recombinant Growth Hormone on Nutritional Status and Pulmonary Function in COPD Rat[J]. Laboratory Animal and Comparative Medicine, 2013, 33(1): 52-55.

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