Abstract: Objective To evaluate the intraocular biocompatibility by observing inflammatory reaction after implantation of SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens (IOLs) in rabbits. Methods Left eyes were performed phacoemulsification with SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens implantation and right eyes were performed phacoemulsification with SN6AD AcrySof IQ ReSTOR multifocal intraocular lens implantation in 24 rabbits. All of the eyes were examined with slitlamp microscope and measured the intraocular pressure at the 1st, 7th days and 1st,3rd,6th months postoperatively. The explanted IOLs were assessed for optical properties. The enucleated eyes were performed histopathological evaluations. Results There were mild corneal edema and anterior chamber flare in both eyes at 1stday postoperatively, obviously improved at 1st week postoperatively, there is no significant difference between two groups during the observation period (P>0.05). Optical testing items of the explanted IOLs were in accord with the requirement of YY0290.2-2009. Histopathological observation showed mild hyperemia of ciliary body and few lymphocytes infiltration. Conclusion The SV25T4 AcrySof IQ ReSTOR multifocal toric intraocular lens has good biocompatibility, meeting for the requirement of safety and validity as material of ocular implants in cataract surgery.

Key words: Intraocular lens (IOLs), Toric, Multifocal, Biocompatibility