Abstract: Objective Keratonosus pathogen and nosogenesis of B6-C0 mouse was studied to infer the cause of human keratonosus pathogeny and to control the disease. Methods Get cornea secretion or cornea scraping from the eyes of normal B6 and B6-C0 mouse at different ages, and introduce them to blood plates and nutrient broth respectively, cultivate them for 24 hours at constant temperature. Pick the bacterium colonies and the suspension in the broth to prepare films, stain the films and examine them under microscope, finally identify the purified bacteria. Results There was difference in cornea bacteriology between normal B6 and B6-C0 mouse. Conclusions The result showed that there was a relationship between the cloudiness of cornea and microbe infection.

Key words: Keratonosus, Bacteriology, Nosogenesis, B6-C0 Mouse