Construction and Preliminary Application of Animal Disease Model Digital Atlas Database Platform

doi:10.12300/j.issn.1674-5817.2024.158

Abstract

Abstract:

Objective Domestic research institutions and researchers have established a wide variety of animal disease models and accumulated a wealth of specialized, distinctive, and targeted atlas data during the model development process. These atlas data are of great value for development and application. Therefore, it is necessary to develop a professional and complete digital atlas database platform for animal models, which can achieve the open sharing of animal model atlas data and the integration and optimization of atlas resources related to disease animal models held by relevant domestic institutions. Methods Based on the B/S architecture, the authors' institution built a digital atlas database of animal models, using Java as the main development language and Oracle database system along with related auxiliary tools. The database platform ran in a Linux environment and could be accessed by users through a web browser. At present, the data on this platform mainly came from the atlas resources submitted by animal model resource units within Guangdong Province. Results In August 2024, a digital atlas database platform for animal models was constructed based on the classification structure of three dimensions: systemic diseases, animal species, and resource units. This platform provided functions such as collection, management, retrieval, and viewing of atlas data. As of January 2025, four resource units had submitted 61 atlas data entries of animal models to the platform, totalling 610 data items. Conclusion The animal model digital atlas database platform has been constructed and put into preliminary use. Although the amount of data on the platform is still limited, it is capable of integrating and openly sharing animal model atlas data. It is believed that with the continuous enrichment of atlas data in the future, this platform is expected to provide important data support for the development of laboratory animal science and comparative medicine research, thereby promoting the efficient utilization of scientific research resources.

Key words: Animal disease models, Atlas data, Database

CLC Number:

Q95-33

LI Huiping,GAO Hongbin,WEN Jinyin,et al. Construction and Preliminary Application of Animal Disease Model Digital Atlas Database Platform[J]. Laboratory Animal and Comparative Medicine, 2025, 45(3): 300-308. DOI: 10.12300/j.issn.1674-5817.2024.158.

Figures/Tables 7

References 18

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字段名 Field name	字段代码 Field code	数据类型（长度） Data type（length）	备注 Note
编码 Code	TXBM	VARCHAR2(30)	即图谱资源类别号，是唯一身份标识符
图谱名称 Atlas name	TXMC	VARCHAR2(200)	图谱资源的具体名称
系统分类 System classification	XTFL	VARCHAR2(20)	图谱所属系统疾病类型
动物分类 Animal classification	DWFL	VARCHAR2(20)	图谱涉及动物种属
文件上传 File upload	TXCFDZ	VARCHAR2(100)	图谱文件上传名称
图谱尺寸 Atlas size	SIZE	VARCHAR2(20)	图谱的统一大小
拍摄时间 Shooting time	PSSJ	DATE	图谱的拍摄时间
上传时间 Upload time	SCSJ	DATE	图谱的上传时间
拍摄说明 Shooting instructions	PSSM	CLOB(4000)	图谱制作说明
描述 Description	TXMS	CLOB(4000)	图谱描述说明
模型说明 Model description	DWSM	CLOB(4000)	动物造模说明
资源单位 Resource facility	ZYDW	VARCHAR2(20)	图谱资源的来源单位/研究者
图谱状态 Atlas Status	TXZT	NUMBER	用数字形式表示图谱是暂存，还是已发布的状态

字段名 Field name	字段代码 Field code	数据类型（长度） Data type（length）	备注 Note
编码 Code	TXBM	VARCHAR2(30)	即图谱资源类别号，是唯一身份标识符
图谱名称 Atlas name	TXMC	VARCHAR2(200)	图谱资源的具体名称
系统分类 System classification	XTFL	VARCHAR2(20)	图谱所属系统疾病类型
动物分类 Animal classification	DWFL	VARCHAR2(20)	图谱涉及动物种属
文件上传 File upload	TXCFDZ	VARCHAR2(100)	图谱文件上传名称
图谱尺寸 Atlas size	SIZE	VARCHAR2(20)	图谱的统一大小
拍摄时间 Shooting time	PSSJ	DATE	图谱的拍摄时间
上传时间 Upload time	SCSJ	DATE	图谱的上传时间
拍摄说明 Shooting instructions	PSSM	CLOB(4000)	图谱制作说明
描述 Description	TXMS	CLOB(4000)	图谱描述说明
模型说明 Model description	DWSM	CLOB(4000)	动物造模说明
资源单位 Resource facility	ZYDW	VARCHAR2(20)	图谱资源的来源单位/研究者
图谱状态 Atlas Status	TXZT	NUMBER	用数字形式表示图谱是暂存，还是已发布的状态

模型类别 Model category	模型图谱名称 Model atlas name	数量/幅 Quantity/piece	数据项/个 Data item/item	资源单位 Resource facility
心血管系统疾病 Cardiovascular diseases	SGTA基因敲除小鼠模型	14	140	广东药科大学
消化系统疾病 Digestive diseases	Par3L基因敲除小鼠模型	3	30	广州医科大学
	DSS诱导的长爪沙鼠溃疡性肠炎模型	5	50	中山大学附属第六医院
	长爪沙鼠放射性直肠炎模型	4	40	中山大学附属第六医院
泌尿系统疾病 Urological diseases	APC^Min/+基因敲除小鼠肠道腺瘤模型	10	100	广东药科大学
骨骼系统疾病 Musculoskeletal disorders	强直性脊柱炎食蟹猴模型	25	250	广东省生物技术研究院（广东省实验动物监测中心）

模型类别 Model category	模型图谱名称 Model atlas name	数量/幅 Quantity/piece	数据项/个 Data item/item	资源单位 Resource facility
心血管系统疾病 Cardiovascular diseases	SGTA基因敲除小鼠模型	14	140	广东药科大学
消化系统疾病 Digestive diseases	Par3L基因敲除小鼠模型	3	30	广州医科大学
	DSS诱导的长爪沙鼠溃疡性肠炎模型	5	50	中山大学附属第六医院
	长爪沙鼠放射性直肠炎模型	4	40	中山大学附属第六医院
泌尿系统疾病 Urological diseases	APC^Min/+基因敲除小鼠肠道腺瘤模型	10	100	广东药科大学
骨骼系统疾病 Musculoskeletal disorders	强直性脊柱炎食蟹猴模型	25	250	广东省生物技术研究院（广东省实验动物监测中心）