Abstract: Objective To investigate the heredity the of olfactory receptor genes between the parents and the filial generation of German shepherd dog. Method Olfactory receptor genes of the parents and the filial generation of German shepherd dog were amplificated using the routine PCR method, and the related olfactory receptor genes were sequenced and analyzed. Result Olfactory receptor genes differed much more between the filial generation and the male parent than between the filial generation and the female parent. The T to C, G to C, A to G, C to T, G to T, T to A and G to A transitions were the main mutation type between parents and the filial generation. Some transitions resulting in the alteration in the protein sequence. Conclusion The results will be helpful to the research on the polymorphism and the heredity rule of canine olfactory receptor genes.

Key words: Olfactory receptor gene, Sequence analysis and comparison