Abstract: Objective To observe the function of anti-inflammation，abirritation and lowering uric acid of effective fractions in Modified “Si miao Powder”. Methods The pain reaction of mouse by chemical stimulation，the ear swelling of mouse induced by xylene and hyperlithuria model were adopted to observe the anti-inflammation，abirritation and lowering uric acid effect of Modified “Si miao Powder” and its effective fractions. Result Modified “Si miao Powder” can fall the uric acid in 3h to the hyperuricemia mouse (P＜0.05) and has obvious paregoric effect to the writhing response mouse stimulated by acetic acid (P＜0.01). The large dose of A fraction can obviously reduce the high uric acid level (P＜0.01)，It displays the obvious anti-inflammation and the analgesia function to ear swelling mouse by xylene and writhing response mouse by acetic acid (P＜0.01).In the A fraction the middle dosage group serum can reduce the mouse high uric acid level in 1 h，3 h (P＜0.05，P＜0.01). It has obvious inhibitory action to ear swelling mouse and writhing response mouse (P＜0.01).The low dosage group of the can suppress the serum uric acid (P＜0.05) and has obvious inhibitory action to ear swelling mouse (P＜0.01)， but has not displayed the analgesia function. Conclusion Effective fractions of the Modified “Si miao Powder” is the material basis, its groups showed some, dose-effect relationship i in ruducing uric acid analgesia, fall the uric acid and the anti-inflammation aspect.

Key words: Modified Si miao Powder, Effective fractions, Hyperuricemia