Abstract: Objective A mathematical model for hypoxic response of the central nervous is presented Method The model is built on Matlab/Simulink system. It combines the models of heart,systemic and pulmonary circulation systems together. The model is composed of carotid sinus baroreceptor afferent path,synpathetic nerve together with hypoxic response of the central nervous system and reflex effector. Results The simulation experiments showed that hypoxic response of the central nervous system plays an inportant part in cardiovascular system. Conclusion The（feveloped model was an effective means to simulate the kinetics of hypoxia.