Abstract: Objective To observe the changes of the biochemical index and pathology of the rabbit liver acutely poisoned by poisonous mushroom. Methods The rabbits were i.g with toxins from Amanita fuliginea at the dosage of 0.05、0.1, 0.2g/kg respectively, and the matched control with 0.9%NS. The biochemical index of liver were observed in every two days, the rabbits were sacrificed after 120 hours, and the pathologic changes of the liver were examined. Results Liver function of the control is normal. Liver function of test groups were damaged with different degree, degeneration or necrosis happen in liver cell, inflammatory cells are in a vessel or a leaf. Conclusion Aniatoxins can damage to liver function of rabbit, and the injury is more obvious depended on the amount of toxins. For making the proper animal model, acutely poisoned by Amanita fuliginea, should choose to give the toxins at the dosage of 0.1g/kg.

Key words: Acute poisoning, Amatoxins, Animal model