Abstract: Objective Effects on the lipid and bone metabolism were discussed by nutrient restriction in aged mice. Methods The male KM mice of 12 month age were used for the nutrient restriction plan that 30% off total energy a day during 12 weeks. The same amounts of 3,7 and 12 month age, male KM mice were used as the young, adult and aged control group respectively. The changes of body weight, triglyceride （TG） content and bone mineral density （BMD） were tested. Resu. ts There was a significant decrease of body weight in the restriction group in the second, third week, then become a slow decrease. Compared with the aged control, TG was lower in the restriction group （P＜0.05）. Compared with the adult and aged control group respectively, there was no significant difference on BMD of the restriction group. Conclusions 30% off nutrient restriction plan induced the TG decreasing significantly and BMD was influenced by the synthetic factors in bone metabolism.