Laboratory Animal and Comparative Medicine ›› 2005, Vol. 25 ›› Issue (4): 215-217.

   

Establishing Mice Model of Multidurg Resistance of Tumor Induced by Combined-chemotherapy

  

  1. 1.Shandong Center for Disease Control and Prevention, Jinan 250014, China；2.Teaching Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011，China；3.Shandong Academy of TCM, Jinan 250014, China；4.Shandong Provincial Center of Laboractory Animal Jinan 250015, China

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Abstract: Objective To establish the mice model of multidurg resistance of tumorous expression in ascites with SI80 cell. Methods The mice with SI80 cell in ascites were treated with the method of PFC of repeated-combined-chemotherapy in less than the therapy dose for 4 weeks. The levels of P170 and LRP and TOPOⅡ were detected by Flow Cytometry Analysis. Results The cellular multidurg rdsistance of tumorous expression （P170 and LRP） and the activity of TOPOⅡ of mice were improved obviously and the expression was stable in the cell line.

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