Abstract: Objective:“Caihe No. Ⅰ、Caihe No.Ⅱ”is a preparation made from pure herbal medicine and has been using for frosbite treatment in human for a long time. Its therapeutic effect on rabbit was evaluated here. Methods ： Silver dollar was frozen by liquid nitrogen （-196℃） and sticked closely onto the skin of the rabbit to establish grade Ⅱ frostbite animal model. The therapeutic effect of “Caihe No. Ⅰ、Ⅱ”was analyzed with the control group. Results:① Pathological changes occurred for Ⅱ degree to deep Ⅱ degree at 5s after frostbite.② After 4 day-period treatment of “Caihe No. Ⅰ、Ⅱ，I degree frostbite were healed. There was significant difference between “Caihe No. I、Ⅱ” and the control group. Conclusion: “Caihe No. Ⅰ、Ⅱ ” have therapeutic effect for frostbite in rabbit. “Caihe No. Ⅰ”is a decoction,while “Caihe No. Ⅱ”is a cream, and the latter is more convenient for pernio in winter. The results of the experiment is same as the clinical result, so its curative effect is reliable.

Key words: Caihe No. I , Caihe No. Ⅱ , Frostbite, Cure, Rabbit