Abstract: The blood pressure （BP），heart rate, body weight and organ weight related to hypertension were monitored and detected in SHR through five generations，the results showed that the SHR had formed hypertensive characters，the average BP in adult SHR was 189±6 mmHg nearly equal to the original SHR （193 mmHg）.From 6th week the hypertensive character was appeared in SHR and the BP increased gradually thereafter，reached highest level on 25th week in male （200±9mmHg） and 17th week in female （178±7mmHg）.The BP levels of SHR in different ages were significantly higher than that of the background strain （WKY），whereas the body weight （BW） were lower than WKY，about 86% of WKY on birth and 67% at the age of 100 days .The organ coefficient of the brain and kidney were higher than that of WKY. Both the weight and organ coefficient of the heart and hypophysis were significantly higher than those of WKY .In period of disease development，SHR also appeared typical pathological changes in cardiovascular system. These pathological changes could cause heart hypertrophy and combining symptoms in heart, brain and kidney.

Key words: Animal model , SHR , Pathological changes , Organs coefficient