›› 2001, Vol. 21 ›› Issue (1): 26-28.
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Abstract: Restenosis is one of the major limitations of PTCA and CABG, it can be as-sumed as a combination of neointima formation and arterial remodeling in response to in-jury. We rcccnlly established model with mice BALB/cA and C57BL/6J. After ligation of the left common carotid artery just proximal to the bifurcation resulting in 90% re-duction of lumen area by a combination of intimal hyperplasia together with decreased diameter. In this study, neointima formation in C57BL/6J micc and BALB/cA mice was compared. Two and four weeks after the ligation, lcukocyte infiltration was observed in the developing neointima, a 90% reduction of luminal area was observed in C57BL/6J ; While in BALB/cA no neointima formation was observed. Conclusion : Vascular remod-eling with neointima formation was the cause of restenosis, presumably by mediating leukocyte recruitment and the interaction between platelets and leukocytes.
Key words: Restenosis , Remodeling , Neointima formation
MU Jun-sheng, ZHU Hong-sheng. Experimental Study on Vascular Restenosis after Ligatation of the Left Common Carotid Artery in Two Strains of Mouse[J]. , 2001, 21(1): 26-28.
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https://www.slarc.org.cn/dwyx/EN/Y2001/V21/I1/26