›› 1997, Vol. 17 ›› Issue (4): 197-198.

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Relationship between Age and Histamine-induced Airway Reactivity in Guinea Pigs

  

  1. Laboratory Animal Centre,Zhe jian Medical U niversity , Hangzhou,310031
  • Received:1997-06-04 Online:1997-01-25 Published:2013-03-19

Abstract: The relationship between the different ages (3、10、22weeks) and histamine - induced airway reactivities was studied in conscious and unrestrained guinea pigs. The result showed that the difference of histamine - induced airway reactivities between 3 and 10 week - old animals was not significant (P>0.05),but the response to histamine in 22 week - old animals was reduced significantly as compared with those in 3 and 10 week - old guinea pigs (P<0.01). And it was suggested that 7~10 week - old guinea pigs may be the most suitable for asthma experiment.

Key words: Guinea pig, Histamine, Airway reactivity, Age