Abstract: Nude mice transplanted with human stomach adenocarcinoma (SGC-7901) were injected with parvovirus H-1 around the site where SGC-7901 was inoculated. The group treated with the virus at 2×10⁷/kg twice a week for 3 weeks showed high tumor inhibition at the rate of 58. 5%. No apparent efficacy was found in the group treated intraperitoneally with parvovirus H-1 at the same dose schedule. The toxicity of parvovirus H-1 seemed to be very low,no toxic reaction was found when 10⁹/kg of the virus was injected intraperitoneally in KM mice.

Key words: Nude mice Human stomach adenocarcinoma, Experimental therapy, Parvovirus H -1