Abstract: In order to evaluate the therapeutic efficacy of high intensity focused ultrasound (HIFU) for treatment of human liver cancer，a suitable large animal model bearing liver tumor is indispensible. Hepatic pseudotumors in 15 rabbits were established by operative injection of 1—2ml Freund’s complete adjuvant into the desirable site of the liver,the pseudotumors were developed in all the animals 7 days after the injection. Another 5 rabbits were injected percutaneously under sonographic guidance»4 of them developed pseudotumors. Autopsies revealed that the pseudotumor was a well-formed lesion of approximately lcm in diameter in the liver. Histologically，the lesion was an inflammatory granuloma. This model showed the following advantages:①easy to be induced with a high successful rate；②a short latent period ； ③the tumor can be detected easily by sonography, CT and MRI ,and showed the characteristic changes in these imaging modalities.

Key words: "Rabbit, Hepatic pseudotumor, Animal model, Imaging features "