Abstract: Three animals (Lagurus lagurus)obtained from Tian Shan area in Xinjiang were inoculated intraperitoneally with Leishmania infantum isolated from Phlebotomus major wui in Xiao Guai area, and were killed for histopathological examination 5 months after the inoculation.The results showed that various numbers of Leishmania were found in spleen, liver, bone-marrow, lymphonodi, kidneys and ureters,and induced similar histopathological changes as seen in human visceral leishmaniasis, suggesting that L. lagurus might be a kind of ideal experimental animal for the duplication of visceral leishmaniasis.