Abstract: Animal models are key foundation for the research on the pathogenesis of emerging infectious diseases and the development of targeted vaccines and drugs, which play an irreplaceable role in deepening the scientific understanding of new infectious diseases and developing the effective prevention and control measures. In this paper, three kinds of emerging viral infectious pathogens (coronavirus, flavivirus and influenza virus) which are seriously harmful to human life and health in recent years are reviewed. The construction and application of the corresponding experimental animal models are briefly described, and their pros and cons are compared, so as to provide a reference for selecting the appropriate animal models for the further research on pathogenicity mechanism and the studies on vaccines and drugs against those emerging viruses.

Key words: Coronavirus, Flavivirus, Influenza virus, Infected animal models