Abstract:

Objective Using New Zealand white rabbits as an animal model, the effectiveness and safety of a domestic porcine small intestinal submucosa (SIS) acellular matrix in repairing rabbit dura mater defects were evaluated by observing the physiological state, clinical manifestations, and pathological changes. Methods Forty-eight New Zealand white rabbits were randomly divided into a trial group (n=24) and a control group (n=24). The domestic SIS and commercially available materials (control) were implanted by surgery. The animals were sacrificed at 7, 30, 60, and 90 days after surgery for anatomical observation and histopathological analysis. All the animals were clinically observed during the study. Results Both SIS materials were able to heal the dura mater 30 days after surgery. There were no obvious clinical abnormalities or significant differences in animal survival rates between the two groups. The morphological changes showing tissue reconstruction were similar at multiple time points, and no infectious inflammatory responses were observed following pathological histological examination in either group. Conclusion Under the conditions of this trial, the repairing effect of the tested domestic SIS was similar to that ovserved in the control group, demonstrating that this type of SIS is an ideal material for dura mater repair.

Key words: Porcine small intestinal submucosa, Acellular matrix, Dura mater, Rabbit model