Abstract: Objective Establishing anger-out and anger-in inducing emotional diseases macaque model to provide suitable research object for brain center mechanism of anger-out and anger-in inducing emotional diseases. Methods Using female macaque and inducing anger emotion occurence, then applying “Emotional evaluation scale of female experiment macaque”to score different emotion type of macaque model. We will differentiate anger-out and anger-in types from all anger monkeys based on scale scores and finish evaluating different anger types. Using anger-out and anger-in monkeys individu-ally add to pressurization method to prepare anger-in or anger-out inducing emotional diseases monkey model. Results After modeling stress，anger factors of PMS liver-qi invasion model monkeys increased significantly than control team(P＜0.05), while PMS liver-qi depression model monkeys had a notable change compared with control team(P＜0.05). While there is no difference compared with control team (P＞0.05) after administration. Conclusion It could be inferred that target disease could be induced successfully using social surbodination stress according to results of 30-minute group ad libitum obser-vation and scale scores, subjective combined objective results were regarded as a good measure methods to evaluate target emotional disease occurence on macaque. Idea and method mentioned above provide a suitable research object for occurrence pathogenesy of anger-out and anger-in emotion inducing emotional disorder.

Key words: Anger-out, Anger-in, Premenstrual Syndrome, Macaque model, Emotional evaluation scale