Abstract: Objective To observe the function of anti-inflammation, abirritation, activating blood circulation and alleviating soft tissue injuries of “Guo heng extract”. Methods The ear swelling of mouse induced by xylene, foot edema caused by carrageenan, the pain reaction of mouse by chemical stimulation, traumatic skin ccchymosis of rat and acute soft tissue injury model were adopted to investigate the treatment effects of the drug. Result The three dosage groups displayed significantly anti-inflam-mation and the analgesia function to ear swelling and foot edema of mouse, and writhing response mouse stimulated by acetic acid. The middle and high dosage groups could promote blood circulation and mitigate soft tissue injuries. Conclusion “Guo heng extract” had obvious anti-inflammation and the analgesia function. It also had the inhibitory action to skin ecchymosis and soft tissue injuries, and showed some dose-effect relationship.

Key words: Guo heng extract, Anti-inflammation, Analgesia;Blood circulation, Soft tissue injuries