Abstract: As morbidity of asthma was increasing in recent years, it was necessary to investigate the etiology, pathology, treatment of bronchus asthma. But there were many limitations to study in human, so that the animal model of asthma played a Irreplaceable role in asthma investigation. In recent years, more and more animal asthma models were applied to further elucidate the pathology, physiology, and the machanisms of immunity. And study in animal also gave us many results which can not achieved in human body. Even in the aspects of development of new drugs, animal model gave us the experimental therapy that can not applied in human. Here, the established animal asthma models and interrelated sensibilization substances were reviewed.

Key words: Bronchus asthma, Animal model.