Abstract: Objective To investigate the combination effects of dimercap to succinic acid(DMSA)， vitamin C and L-methioine on the ICR mice induced by lead. Methods The mice of the experimental group were exposed to 0.1% lead acetate in drinking water for 6 weeks，which were randomly divided into model control group，low dosage group of DMSA，high dosage group of DMSA and group of low dosage of DMSA combined with vitamin C and L-methioine. Afler 4 weeks of treatment ,the concentration of lead in blood was detected, and the morphological changes of liver cells was observed by Hematoxylin and Eosin Staining. Results The difference of the concentration of lead in blood of model control group was more higher than those of low dosage group of DMSA ,high dosage group of DMSA or group low dosage of DMSA combined with vitamin C and L-methioine (P＜0.01). The difference of the concentration of lead in blood between normal group and model control group was very significant (P＜0.01). The liver cells appeared hydropic degeneration and the effect of combination group was significantly superior to other groups. Conclusion The effect of lead excretion for treating of DMSA combined with vitamin C and L-methioine more better than others.

Key words: Lead, DMSA, Vitamin C, L-methioine