Abstract: Objective The purpose of this study was to investigate the anatomic parameter of the rabbit tibia, and to design intramedullary nailing model on the rabbit tibia fracture faxition according to the medullary cavity anatomic feature. Method Eighteen adult New Zealand white rabbits (2.8?3.0 kg) were used in the study. Both sides of the tibia were harvested and transverse computed tomographic scanning was conducted in the interval of every 5 mm and the internal diameters were messured. The intramedullary nail for tibia fracture faxition was designed according to the rabbit tibia medullary cavity anatomic feature. The osteotomy was conducted at the board of upper and middle part of tibia. The models of tibia fracture intramedullary faxition were done. Result The shape in medullary cavity transverse section of upper part of the tibia was triangular. That of the lower part was oval. While the middle part was the transform of the two shapes. The intramedullary nail was designed according to the anatomic characteristics with it，s transverse section being triangular. The fixation was satisfactory. Conclution The intramedullary nail designed according the anatomic feature of the rabbit tibia medullary cavity and the intramedullary nailing model on the rabbit tibia fracture faxition was rational.