Abstract: There are mainly two kinds model of prostatitis: bacterial and nonbacterial prostatitis. E.coli as the primary etiologic agent causes acute and chronic bacterial prostatitis. Nonbacterial prostatitis is often induced by chemical agents or biological angents. Compared with chemic-induced model, the biologies-induced prostatitis has more specific, which is an ideal prostatitis model. The concrete methods include estradiol-indued and male accessory gland(MAG) extracts in complete Freund’s adjuvant (CFA)-induced prostatitis. These models can provide methods and evidences for basic and clinical research.