Abstract: Objective To evaluate the therapeutic effects of Tangxinkang on diabetic cardiomyopathy in rat and discuss its mechanism .Methods The model rats were established by ip STZ and hyper-calorie diet. The glucose metabolism、insulin、myocardium histomorphology and nuclear factor-kappa B (NF-kB) were studied and the therapeutic mechanism in biology of Tangxinkang treating the diabetic myocardial damage were also discussed. Results (1) Tangxinkang has good effects on decreasing glucose and HbAlc in blood and increasing the level of insulin. (2)Tangxinkang has good repairing effect on damaged cardiac muscle and pancrease in histomorphologic change.(3)Tangxinkang has obvious adjustment role on over-expressed NF-kB of diabetic cardiac muscle (P＜0.01). Conclusion Tangxinkang has an obvious therapeutic role on diabetic cardiomyopathy through adjusting the over-expressed NF-kB of diabetic cardiac muscle mainly.

Key words: Tangxinkang, Diabetic Cardiomyopathy, Nuclear factor-kappa B