Abstract: Objective To compare the effects of Pentobarbital sodium and Urethane on neural discharge of hippocampal CA1 region in mice, and to investigate the changes of field potentials and neural firing rates of hippocampal CA1 region after injected two anesthetic agents respectively. Methods Five male C57BL mice were used in this study. 12 tetrodes were implanted separately on the both sides of hippocampal CA1 region. Local field potentials and the neural firing activities were recorded by using the multi-channel recording technology. Results It showed the changes of field potentials and neural firing rates in hippocampal CA1 region under anesthetization of Pentobarbital sodium and Urethane respectively. Conclusions There are different effects of two anesthetics on hippocampal neural discharge and field potentials, suggesting that Pentobarbital sodium and Urethane have different mechanisms underlying neural firing activities.

Key words: Neural firing activities, Hippocampus, Anesthetic