›› 2007, Vol. 27 ›› Issue (2): 119-122.
Special Issue: 实验动物设施设备
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Abstract: Objective To evaluate the biocompatibility which include blood、muscle and genotoxicity of coronary stents in rabbits. Methods Cased on ISO 10993-10,the assessments of biocompatibility were identified by experiment of the blood compatibility, genetic toxicity test and local reactions of muscle embedding test. Results 1. Coronary stents had no effects on the coagulation system of the rabbits 2. The histopathology and clinical anatomical observation of the local muscle were normal and no chromosome aberration . 3.The package remained sterile and no leakage were found. Conclusion 1. In rabbits coronary stents had no effects on the coagulation system,no local irritative reaction and genotoxicity as well. 2.The package remained no leakage and the efficacy of the package in blockage of bacteria appeared to be very effective.
Key words: Blood-compatibility, Genotoxicity, Bio compatibility Chromosomal aberration
FANG Jing-yi,LIU Qing-fang. Systematic Evaluation on Biocompatibility of Coronary Stents[J]. , 2007, 27(2): 119-122.
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https://www.slarc.org.cn/dwyx/EN/Y2007/V27/I2/119