Abstract: Objective Explore the effect of long-distance transportation on cardiac performance in sub-health Beagle dogs to provide a reference for the assessment of sub-health status. Methods Twelve Beagle dogs were selected in this study，six of them were fatigued by long-distance transportation, and another six as control. Blood routine，liver and kidney functions，myocardium enzyme indexes, blood sugar, electrocardiograms indexes were tested one day later. The long-distance transportation of fatigue group were confirmed as sub-healthy according to the SO2 index and clinical sub-healthy diagnostic criteria，and the cardiac performance were monitored by cardiac catheter technology. Results The average arterial pressure (MAP) and the average systolic blood pressure (SAP) in sub-healthy group are markedly lower compared with the healthy group，and the cardiac performance indexes left ventricle systolic pressure (LVSP), the left ventricle pressure (LVP), P@dp/dt_{max, +dp/dtmax, -dp/dtmax，the muscle fibres shorten rate (Vce-40，Vce(p@dp/dtmax), Vpm) significantly decreased(P-20) decreased，but the difference is not significant (P>0.05) .The total area of mental efforts loop (At)，the area of mental efforts during the contraction period (As) and the diastolic period (Ad) are markedly lowered (P0.05). Conclusion The contraction of the heart and diastole functions showed disorder in a sub-healthy state because of lower capacity to resist stress, and thus contraction in the heart, dilate during martial function can not be effectively adjusted. Therefore the use of cardiac function indexes to assess sub-health state has certain reliability and act as a reference in the clinical diagnosis and pharmacological studies.}

Key words: Long-distance transportation, Sub-health, Blood pressure, Cardiac performance, Beagle dogs