Abstract: Objective To establish the modified athesclerotic plaque model and evaluate it compared with traditional animal model. Methods New Zealand rabbits were fed with high cholesterol diet and feromal artery balloon injury were conducted to establish the improved atherosclerotic plaque model, PT and endothelium thickness, foam cell area were determined, and TIMI was monitored. Result Compared with the traditional group, modified plaque model group presents significant stenosis of the femoral artey，shortening of the PT and thickening of the endothelium. Conclusion The modified plaque model, which is accurately controlled and easily repeated, could be used to evaluate the progress of atherosclerosis and demonstrate the mechanism of the plaque.