Abstract: Bacteria can induce apoptosis of the mouse macrophage through its virulent substances such as endotoxin , exotoxin, invasin etc. This is a strategy used by bacterial pathogens to overcome host defense. The changes of morphology and biochemistry or biophysical characters of its membrane may be occurred in apoptosic macrophage. The apoptosic macrophage elicit an inflammaton by secretion of proinflammatory cytokines , which is an important factor causing infection limited. The study on the interaction between bacterial and macrophage apoptosis would be important in the development of the therapy and prevention of infectious diseases. We reviewed the advance in the mechanism and checking methods of mouse macrophage apoptosis induced by bacterial infection.

Key words: Bacterial, Infection, Macrophage, Apoptosis