Laboratory animal husbandry management, biosafety risk assessment, and ethical review of laboratory animals are core tasks of university laboratory animal centers. The Laboratory Animal Center of Zhejiang University reformed the informatization of the laboratory animal management process based on the framework of information management system combined with its own operation characteristics. It has established a full-process informatization system for supervising from project review, project implementation, to project final approval. The system has improved the efficiency of husbandary management, and strengthened the biosafety and welfare ethics of laboratory animals, providing a new idea for the management of laboratory animals in colleges and universities

The establishment of a network information platform for a centralized procurement system for laboratory animals in colleges and universities has made the inventory supply and settlement management of laboratory animals centers more systematic, convenient, and scientific. The application of this system in the Laboratory Animals Department of Capital Medical University was examined, and the results showed that the establishment of a clear centralized procurement management module could greatly save labor and time, improve the work efficiency, and standardize procurement and supply personnel. The findings strongly suggested that the network informatization of the centralized procurement system of laboratory animals in colleges and universities is necessary.

Objective To explore the natural infection status of Streptococcus pneumoniae in captive bred rhesus macaques, and to provide reference for the clinical diagnosis and treatment of Streptococcus pneumoniae infection. Methods Twenty infant monkeys, 30 adult monkeys and 30 elderly monkeys were randomly selected from a rhesus macaques population, and the nasal swabs and pharynx swabs were collected and screened for Streptococcus pneumoniae simultaneously by bacterial culture and real-time fluorescent quantitative PCR. The mother monkeys of the positive infant monkeys were screened for Streptococcus pneumoniae. Gram staining method, Optochin drug sensitivity test, bile solubility test, inulin fermentation test and PCR amplification and sequencing were used to further identification. Results The positive rate of rhesus macaques carrying Streptococcus pneumoniae was 20% (4/20), and the mother macaques of the four positive infant macaques tested negative. The positive rate was 0% in both adult and elderly rhesus monkeys. The morphological observation results of the bacterial culture showed that the bacteria appeared gray and raised, and produced a surrounding green zone of hemolysis with a flattened center, indicating typical Streptococcus pneumoniae colony characteristics. The results of Gram dyeing, bile dissolution test, and inulin fermentation test were all positive, and the bacteria were sensitive to Optochin. The above results showed that the four strains isolated from the infant monkeys’ nasopharyngeal swabs were Streptococcus pneumoniae. Conclusion The investigation findings show that Streptococcus pneumoniae is mainly found in the noses and throats of 20% infant monkeys among rhesus macaques, and no vertical transmission from mother to child is found.

Objective To establish inspection methods for materials carried into barrier facilities housing specific pathogen-free (SPF) laboratory mice. Methods Experimental materials brought into a murine barrier facility were collected. Non-cellular material samples were cultured to identify whether samples harbored bacteria, and cell samples were screened for the presence or absence of mycoplasma using PCR. Results A total of 14 708 experimental materials were collected and evaluated over a 5-year period. The average positive rate for bacterial detection in 13 085 non-cellular samples was 1.99%, and the positive rate for mycoplasma in 1 623 cell samples was 4.81%. Positive detection rates for bacteria and mycoplasma have gradually decreased and have remained at low levels over recent years. Conclusion sIt is feasible to conduct continuous large-scale inspection, monitoring, and control of experimental materials used in animal barrier facilities. Inspection processes can strengthen the confidence of researchers performing aseptic treatment with animal experimental materials and enable facility managers to evaluate risks from experimental materials. Experimental material inspection is an effective measure for microbial quality control in SPF experimental mice.

Health code is a form of two-dimensional electronic certificate with personal real data. It can greatly improve management efficiency when applied to the supervision of administrative licenses involving laboratory animals in the process of production, transportation, and use. According to the characteristics of provincial territorial management of laboratory animals, a unified information interface standard should be established to realize national mutual recognition for promoting industrial circulation. This would represent a development trend under 5G conditions such that network management of laboratory animals on the fixed end is transformed into information management of laboratory animals on mobile handsets.

In view of the complex situation of the management of the laboratory animal in colleges and universities, this paper analyzes the key elements of the management, explores the information management system suitable for the experimental animal in colleges and universities, gives full play to the standardization and intelligence of the management, and provides guarantee for the teaching and scientific research in colleges and universities. By introducing the design ideas and functional modules, this paper summarizes the new laboratory animal information management system .