Abstract: Objective To observe the antitumor effect of paclitaxel- novel copolymer of poly lactic acid phosphate (PLCE) microspheres on proliferation of ovarian cancer. Methods The human overiam cancer (HO8910) were implanted into the ovarian capsule of 68 nude mice. Three weeks later, 42 tumor bearing nude mice were randomly divided into 7 groups as follow, blank control group, negative control group, paclitarel injection group, paclitaxel-PLCE microspheres 1 high and low dose group, and paclitaxel-PLCE microspheres 2 high and low dose group, with 6 nude mice in each group. The drug was administered 1 time a day, and the growth of the tumor were continuously observed for one month. Results The tumor inhibition rate of paclitarel injection was 57.0%, and tumor inhibition rate of paclitaxel-PLCE microspheres 2 high and low dose group were 77.1% and 58.7% respectively. Conclusion Paclitaxel-PLCE microspheres have a strong inhibitory effect on HO8910 ovarian cancer transplanted in nude mice.

Key words: Paclitaxel, Microspheres, Ovarian cancer, Poly lactic acid phosphate (PLCE)