自主神经调节剂对房颤模型大鼠心房电重塑及组织病理变化的影响

李嘉菲, 张朕豪, 王硕, 田歌, 温爽, 闫玉雪, 崔然, 叶振, 崔永春

Effects of Autonomic Neuromodulators on Atrial Electrical Remodeling and Histopathological Changes in a Rat Model of Atrial Fibrillation

LI Jiafei, ZHANG Zhenhao, WANG Shuo, TIAN Ge, WEN Shuang, YAN Yuxue, CUI Ran, YE Zhen, CUI Yongchun

图1 自主神经调节剂诱发大鼠心房电生理特征变化 注：A，实验流程图；B，大鼠体表心电图的代表性图片；C，大鼠离体心脏单次50 Hz起搏2 s后的心电图，红框内为代表性心房颤动心电图谱；D~F，离体心脏电生理检测房颤诱发率、心房电传导速度和心房传导离散度（n=3）；G，左心房电活动传导代表性等时图（含传导时间和离散时间）。ECG，心电图；AF，房颤。与对照组相比，*P<0.05，**P<0.01。

Figure 1 Autonomic neuromodulators induce changes in atrial electrophysiological characteristics in rats Note： A， Experimental flowchart； B， Representative images of rat surface electrocardiograms； C， Electrocardiograms of isolated rat heart after a single 50 Hz burst pacing for 2 s， with the red box indicating a representative atrial fibrillation tracing； D-F， Ex vivo cardiac electrophysiological assessment of atrial fibrillation inducibility， atrial conduction velocity， and atrial conduction dispersion （n=3）； G， Representative isochronal maps of left atrial electrical activity conduction （including conduction time and dispersion）. ECG， electrocardiogram； AF， atrial fibrillation. *P < 0.05， **P < 0.01， compared with the control group.