基于miRNA测序分析清肺排毒汤防治小鼠急性肺损伤的分子机制研究

李龙雪, 万崇凡, 张琦, 雷茹婷, 王潇玥, 程乐妍, 赖琦, 刘荣华, 刘漩, 徐铁龙

Molecular Mechanisms of Qingfei Paidu Decoction in the Prevention and Treatment of Acute Lung Injury in Mice Based on miRNA Sequencing

LI Longxue, WAN Chongfan, ZHANG Qi, LEI Ruting, WANG Xiaoyue, CHENG Leyan, LAI Qi, LIU Ronghua, LIU Xuan, XU Tielong

表1 各组小鼠的体重、肺系数和血清炎症因子水平比较 (n=8,

\overset{ˉ}{x}

±s)

Table 1 Comparisons of body weight, lung coefficient, and serum inflammatory factors in different groups of mice

组别

Group

初始体重/g

Initial body weight/g

终末体重/g

Final body weight/g

肺系数/%

Lung coefficient/%

TNF-α

ρ/(pg·mL^-¹)

IL-1β

ρ/(pg·mL^-¹)

IL-6

ρ/(pg·mL^-¹)

对照组

Control group

23.3±1.0

28.9±1.5

0.57±0.03

118.3±8.9

19.8±4.4

18.2±3.6

模型组

Model group

23.3±1.4

28.1±1.9

0.75±0.07^∗∗

148.6±13.4^∗∗

24.6±3.3

29.5±7.7^∗∗

QFPDD 组

QFPDD group

23.4±0.8

28.4±1.9

0.73±0.07

131.3±16.9^#

22.2±6.4

21.8±5.0^#