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基于miRNA测序分析清肺排毒汤防治小鼠急性肺损伤的分子机制研究
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李龙雪 1(  ), 万崇凡 2, 张琦 2, 雷茹婷 2, 王潇玥 3, 程乐妍 2, 赖琦 2, 刘荣华 4( )(  ), 刘漩 1( )( ), 徐铁龙 5( )( )
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Molecular Mechanisms of Qingfei Paidu Decoction in the Prevention and Treatment of Acute Lung Injury in Mice Based on miRNA Sequencing
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LI Longxue 1( ), WAN Chongfan 2, ZHANG Qi 2, LEI Ruting 2, WANG Xiaoyue 3, CHENG Leyan 2, LAI Qi 2, LIU Ronghua 4( )( ), LIU Xuan 1( )( ), XU Tielong 5( )( )
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图1. 各组小鼠肺组织HE染色结果
注：对照组，连续8 d灌胃给予超纯水；模型组，第1天灌胃给予超纯水，第2～8天给予脂多糖（LPS）水溶液雾化，建立急性肺损伤模型；QFPDD组，连续8 d灌胃给予清肺排毒汤（QFPDD），并于第2～8天给予LPS水溶液雾化以建立模型。×200标尺为100 μm，×400标尺为50 μm；红色箭头指示炎症细胞浸润，红色五角星指示毛细血管扩张淤血。
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Figure 1. HE staining of lung tissues from mice in different groups
Note： Control group， intragastrically administered ultrapure water for 8 consecutive days. Model group， intragastrically administered ultrapure water on day 1， followed by exposure to aerosolized lipopolysaccharide （LPS） solution on days 2–8 to establish the acute lung injury （ALI） model. QFPDD group， intragastrically administered Qingfei Paidu decoction （QFPDD） for 8 consecutive days， with concurrent exposure to aerosolized LPS solution on days 2–8 for ALI induction. Scale bars： 100 μm （×200） and 50 μm （×400）. Red arrows indicate inflammatory cell infiltration； red stars indicate capillary dilation and congestion.
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