脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图7 脊髓半横断损伤组与脊髓压迫损伤组在术后第7天与第21天表达差异基因的功能富集分析结果 注：A~B，术后第7天，HSCI组和SCC组之间上调和下调差异表达基因的基因本体（GO）富集分析结果；C~D，术后第7天，HSCI组和SCC组之间上调和下调差异表达基因的京都基因与基因组数据库（KEGG）富集分析结果；E~F，术后第21天，HSCI组和SCC组之间上调和下调差异表达基因的GO富集分析结果；G~H，术后第21天，HSCI组和SCC组之间上调和下调差异表达基因的KEGG通路富集分析结果。条形颜色表示相应功能条目的P值，用于反映富集的显著性水平。HSCI组，脊髓半横断损伤组；SCC组，脊髓压迫损伤组。

Figure 7 Functional enrichment analysis of differentially expressed genes between the hemisection spinal cord injury group and the spinal cord compression injury group at postoperative days 7 and 21 Note： A-B， gene ontology （GO） enrichment analysis results of up?regulated and down?regulated differentially expressed genes between the HSCI and SCC groups on postoperative day 7； C-D， Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis results of up?regulated and down?regulated differentially expressed genes between the HSCI and SCC groups on postoperative day 7； E-F， GO enrichment analysis results of up?regulated and down?regulated differentially expressed genes between the HSCI and SCC groups on postoperative day 21； G-H， KEGG pathway enrichment analysis results of up?regulated and down?regulated differentially expressed genes between the HSCI and SCC groups on postoperative day 21. The color of the bars represents the P value of the corresponding functional term， indicating the significance level of enrichment. HSCI， hemisection spinal cord injury group； SCC， spinal cord compression group.