脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图6 脊髓半横断损伤组与假手术对照组小鼠在第7天与第21天的差异表达基因的功能富集分析结果 注：A~B，术后第7天，HSCI组和CTR组之间上调和下调差异表达基因的基因本体（GO）富集分析结果；C~D，术后第7天，HSCI组和CTR组之间上调和下调差异表达基因的京都基因与基因组数据库（KEGG）富集分析结果；E~F，术后第21天，HSCI组和CTR组之间上调和下调差异表达基因的GO富集分析结果；G~H，术后第21天，HSCI组和CTR组之间上调和下调差异表达基因的KEGG富集分析结果。图中条形颜色代表对应功能类别的P值，反映富集显著性。HSCI组，脊髓半横断损伤组；CTR组，假手术对照组。

Figure 6 Functional enrichment analysis of differentially expressed genes between the hemisection spinal cord injury group and the sham-operated control group at postoperative days 7 and 21 Note： A-B， gene ontology （GO） enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the HSCI and CTR groups on postoperative day 7； C-D， Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the HSCI and CTR groups on postoperative day 7； E-F， GO enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the HSCI and CTR groups on postoperative day 21； G-H， KEGG enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the HSCI and CTR groups on postoperative day 21. The color of the bars represents the P value of the corresponding functional category， reflecting the significance of enrichment. HSCI， hemisection spinal cord injury group； CTR， sham-operated control group.