脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图5 脊髓压迫损伤组与假手术对照组小鼠在术后第7天和第21天差异表达基因的富集分析结果 注：A~B，术后第7天，SCC组和CTR组之间上调和下调差异表达基因的基因本体（GO）富集分析结果；C~D，术后第7天，SCC组和CTR组之间上调和下调差异表达基因的京都基因与基因组数据库（KEGG）富集分析结果；E~F，术后第21天，SCC组和CTR组之间上调和下调差异表达基因的GO富集分析结果；G~H，术后第21天，SCC组和CTR组之间上调和下调差异表达基因的KEGG富集分析结果。图中条形颜色代表对应功能类别的P值，反映富集显著性。SCC，脊髓压迫损伤组；CTR，假手术对照组。

Figure 5 Enrichment analysis of differentially expressed genes in the spinal cord compression group compared to the sham-operated control group at postoperative days 7 and 21 Note： A-B， gene ontology （GO） enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the SCC and CTR groups on postoperative day 7； C-D， Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the SCC and CTR groups on postoperative day 7； E-F， GO enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the SCC and CTR groups on postoperative day 21； G-H， KEGG enrichment analysis results of up-regulated and down-regulated differentially expressed genes between the SCC and CTR groups on postoperative day 21. The color of the bars represents the P value of the corresponding functional category， reflecting the significance of enrichment. SCC， spinal cord compression group； CTR， sham-operated control group.