脊髓压迫和半横断损伤小鼠模型的时空基因表达谱及修复机制研究

徐波, 陈泰任, 方乾, 吴际

Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models

XU Bo, CHEN Tairen, FANG Qian, WU Ji

图3 脊髓损伤组小鼠与假手术对照组小鼠在第7天和第21天基因表达差异的火山图 注：A~B，与CTR组相比，SCC组小鼠在术后第7天和第21天基因的表达情况；C~D，与CTR组相比，HSCI组小鼠在第7天和第21天基因的表达情况。红色圆点代表上调的差异表达基因（DEGs），蓝色圆点代表下调的DEGs，灰色点代表表达无显著差异的基因。CTR，假手术对照组；HSCI，脊髓半横断损伤组；SCC，脊髓压迫损伤组。

Figure 3 Volcano plots of differentially expressed genes in spinal cord injury models compared with the sham-operated control group at day 7 and day 21 post-injury Note： A-B， gene expression in the SCC group compared with the CTR group at postoperative day 7 and day 21； C-D， gene expression in the HSCI group compared with the CTR group at day 7 and day 21. Red dots represent up-regulated differentially expressed genes （DEGs）， blue dots represent down-regulated DEGs， and gray dots represent genes with no significant difference in expression. CTR， sham-operated control group； HSCI， hemisection spinal cord injury group； SCC， spinal cord compression injury group.